4KN6

Crystal structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with 6-fluoro-3-hydroxy-2-pyrazinecarboxamide (T-705) ribose-5'-monophosphate

Summary for 4KN6

Entry DOI	10.2210/pdb4kn6/pdb
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, 6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide (3 entities in total)
Functional Keywords	favipiravir, 6-oxopurine phosphoribosyltransferase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00492
Total number of polymer chains	1
Total formula weight	24779.34
Authors	Naesens, L.,Guddat, L.,Keough, D.,van Kuilenburg, A.B.P.,Meijer, J.,Vande Voorde, J.,Balzarini, J. (deposition date: 2013-05-08, release date: 2013-08-14, Last modification date: 2024-02-28)
Primary citation	Naesens, L.,Guddat, L.W.,Keough, D.T.,van Kuilenburg, A.B.,Meijer, J.,Vande Voorde, J.,Balzarini, J. Role of human hypoxanthine Guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Mol.Pharmacol., 84:615-629, 2013 Cited by PubMed: 23907213 DOI: 10.1124/mol.113.087247 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.728 Å)

Structure validation