4K94
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19
Summary for 4K94
Entry DOI | 10.2210/pdb4k94/pdb |
Related | 4K9E |
Descriptor | Fab19 heavy chain, Fab19 light chain, Mast/stem cell growth factor receptor Kit, ... (5 entities in total) |
Functional Keywords | receptor tyrosine kinase (rtk), fab, ig sf, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 72265.44 |
Authors | Resheynyak, A.V.,Boggon, T.J.,Lax, I.,Schlessinger, J. (deposition date: 2013-04-19, release date: 2013-10-16, Last modification date: 2020-07-29) |
Primary citation | Reshetnyak, A.V.,Nelson, B.,Shi, X.,Boggon, T.J.,Pavlenco, A.,Mandel-Bausch, E.M.,Tome, F.,Suzuki, Y.,Sidhu, S.S.,Lax, I.,Schlessinger, J. Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region. Proc.Natl.Acad.Sci.USA, 110:17832-17837, 2013 Cited by PubMed: 24127596DOI: 10.1073/pnas.1317118110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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