Crystal structure of apramycin bound to the leishmanial rRNA A-site

Summary for 4K31

Functional Keywordsrrna duplex, ribosomal a-site, aminoglycoside, ribosome, rna, rna-antibiotic complex, rna/antibiotic
Biological sourceLeishmania
Total number of polymer chains2
Total molecular weight16871.21
Shalev, M.,Kondo, J.,Adir, N.,Baasov, T. (deposition date: 2013-04-10, release date: 2013-07-31, modification date: 2013-09-04)
Primary citation
Shalev, M.,Kondo, J.,Kopelyanskiy, D.,Jaffe, C.L.,Adir, N.,Baasov, T.
Identification of the molecular attributes required for aminoglycoside activity against Leishmania.
Proc.Natl.Acad.Sci.USA, 110:13333-13338, 2013
PubMed: 23898171
DOI: 10.1073/pnas.1307365110
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRSRZ outliersRNA backbone0.2601815.9%0.67MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4k31
no rotation
Molmil generated image of 4k31
rotated about x axis by 90°
Molmil generated image of 4k31
rotated about y axis by 90°
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