4JVG
B-Raf Kinase in Complex with Birb796
Summary for 4JVG
Entry DOI | 10.2210/pdb4jvg/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA (2 entities in total) |
Functional Keywords | kinase, phosphotransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P15056 |
Total number of polymer chains | 4 |
Total formula weight | 131110.39 |
Authors | Lavoie, H.,Thevakumaran, N.,Gavory, G.,Li, J.,Padeganeh, A.,Guiral, S.,Duchaine, J.,Mao, D.Y.L.,Bouvier, M.,Sicheri, F.,Therrien, M. (deposition date: 2013-03-25, release date: 2013-05-29, Last modification date: 2024-02-28) |
Primary citation | Lavoie, H.,Thevakumaran, N.,Gavory, G.,Li, J.J.,Padeganeh, A.,Guiral, S.,Duchaine, J.,Mao, D.Y.,Bouvier, M.,Sicheri, F.,Therrien, M. Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nat.Chem.Biol., 9:428-436, 2013 Cited by PubMed: 23685672DOI: 10.1038/nchembio.1257 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.09 Å) |
Structure validation
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