4JV3

Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with platencin

Summary for 4JV3

Entry DOI	10.2210/pdb4jv3/pdb
Related	3LRF
Descriptor	Beta-ketoacyl synthase, 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid (3 entities in total)
Functional Keywords	ssgcid, beta-ketoacyl synthase, platencin, structural genomics, seattle structural genomics center for infectious disease, transferase-antibiotic complex, transferase/antibiotic
Biological source	Brucella melitensis biovar Abortus
Total number of polymer chains	1
Total formula weight	46148.81
Authors	Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2013-03-25, release date: 2013-05-22, Last modification date: 2023-09-20)
Primary citation	Patterson, E.I.,Nanson, J.D.,Abendroth, J.,Bryan, C.,Sankaran, B.,Myler, P.J.,Forwood, J.K. Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites. Proteins, 88:47-56, 2020 Cited by PubMed: 31237717 DOI: 10.1002/prot.25765 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation