4JOL
Complex structure of AML1-ETO NHR2 domain with HEB fragment
Summary for 4JOL
Entry DOI | 10.2210/pdb4jol/pdb |
Descriptor | Protein CBFA2T1, Transcription factor 12 (2 entities in total) |
Functional Keywords | leukemia; aml1-eto; heb; nhr2 domain, dna binding protein |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q06455 Q99081 |
Total number of polymer chains | 8 |
Total formula weight | 42632.38 |
Authors | Wang, Z.,Patel, D.J. (deposition date: 2013-03-18, release date: 2013-06-26, Last modification date: 2023-09-20) |
Primary citation | Sun, X.J.,Wang, Z.,Wang, L.,Jiang, Y.,Kost, N.,Soong, T.D.,Chen, W.Y.,Tang, Z.,Nakadai, T.,Elemento, O.,Fischle, W.,Melnick, A.,Patel, D.J.,Nimer, S.D.,Roeder, R.G. A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature, 500:93-97, 2013 Cited by PubMed: 23812588DOI: 10.1038/nature12287 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.906 Å) |
Structure validation
Download full validation report