4JKI
Crystal Structure of N10-Formyltetrahydrofolate Synthetase with ZD9331, Formylphosphate, and ADP
Replaces: 3SINSummary for 4JKI
Entry DOI | 10.2210/pdb4jki/pdb |
Related | 3PZX 3RBO 3SIN 4JIM 4JJK 4JJZ |
Descriptor | Formate--tetrahydrofolate ligase, 2,7-dimethyl-6-[(prop-1-yn-1-ylamino)methyl]quinazolin-4(3H)-one, formyl phosphate, ... (6 entities in total) |
Functional Keywords | ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Moorella thermoacetica |
Total number of polymer chains | 2 |
Total formula weight | 121202.71 |
Authors | Celeste, L.R.,Lovelace, L.L.,Lebioda, L. (deposition date: 2013-03-09, release date: 2013-03-20, Last modification date: 2023-09-20) |
Primary citation | Celeste, L.R.,Chai, G.,Bielak, M.,Minor, W.,Lovelace, L.L.,Lebioda, L. Mechanism of N10-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors. Protein Sci., 21:219-228, 2012 Cited by PubMed: 22109967DOI: 10.1002/pro.2005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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