4JK5

Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Ser)

Summary for 4JK5

• Entry DOI: 10.2210/pdb4jk5/pdb
• Related: 3QN7 4GLY
• Related PRD ID: PRD_000926
• Descriptor: Urokinase-type plasminogen activator, bicyclic peptide UK18-D-Ser, uPA inhibitor, SULFATE ION, ... (7 entities in total)
• Functional Keywords: serine protease, chymotrypsin fold, urokinase-type plasminogen activator, bicyclic peptide inhibitor, d-amino acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00749
• Total number of polymer chains: 2
• Total formula weight: 30501.82

Authors

Buth, S.A.,Leiman, P.G.,Chen, S.,Heinis, C. (deposition date: 2013-03-09, release date: 2013-07-17, Last modification date: 2023-09-20)

• Primary citation: Chen, S.,Gfeller, D.,Buth, S.A.,Michielin, O.,Leiman, P.G.,Heinis, C.; Improving binding affinity and stability of Peptide ligands by substituting glycines with d-amino acids.; Chembiochem, 14:1316-1322, 2013; PubMed: 23828687; DOI: 10.1002/cbic.201300228

Experimental method

X-RAY DIFFRACTION (1.55 Å)