4JFN
Crystal structure of the N-terminal, growth factor-like domain of the amyloid precursor protein bound to copper
Summary for 4JFN
Entry DOI | 10.2210/pdb4jfn/pdb |
Descriptor | Amyloid beta A4 protein, COPPER (II) ION, GLYCEROL, ... (4 entities in total) |
Functional Keywords | alzheimer's disease, gfld, app, growth factor-like domain, copper binding, metal binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 1 |
Total formula weight | 18776.02 |
Authors | Wild, K.,Baumkotter, F.,Kins, S. (deposition date: 2013-02-28, release date: 2014-07-23, Last modification date: 2023-11-08) |
Primary citation | Baumkotter, F.,Schmidt, N.,Vargas, C.,Schilling, S.,Weber, R.,Wagner, K.,Fiedler, S.,Klug, W.,Radzimanowski, J.,Nickolaus, S.,Keller, S.,Eggert, S.,Wild, K.,Kins, S. Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain J.Neurosci., 34:11159-11172, 2014 Cited by PubMed: 25122912DOI: 10.1523/JNEUROSCI.0180-14.2014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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