4JDD

14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface

Summary for 4JDD

Entry DOI	10.2210/pdb4jdd/pdb
Related	3MHR 3SMK 3TOM 3UX0 4JC3
Descriptor	14-3-3 protein sigma, Estrogen receptor Peptide, FUSICOCCIN, ... (4 entities in total)
Functional Keywords	14-3-3, adapter protein, protein-protein interaction, signaling protein-peptide complex, signaling protein/peptide
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P31947 Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains	2
Total formula weight	28381.85
Authors	Bier, D.,Ottmann, C. (deposition date: 2013-02-25, release date: 2013-05-15, Last modification date: 2017-06-07)
Primary citation	De Vries-van Leeuwen, I.J.,da Costa Pereira, D.,Flach, K.D.,Piersma, S.R.,Haase, C.,Bier, D.,Yalcin, Z.,Michalides, R.,Feenstra, K.A.,Jimenez, C.R.,de Greef, T.F.,Brunsveld, L.,Ottmann, C.,Zwart, W.,de Boer, A.H. Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface. Proc. Natl. Acad. Sci. U.S.A., 110:8894-8899, 2013 Cited by PubMed: 23676274 DOI: 10.1073/pnas.1220809110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation