4JAR

Crystal structure of mycobacterium tuberculosis pks11 in complex with polyketide intermediates and evidence that it synthesize ALKYLPYRONES

Summary for 4JAR

Entry DOI	10.2210/pdb4jar/pdb
Related	4JAO 4JAP 4JAQ 4JAT 4JD3
Descriptor	Alpha-pyrone synthesis polyketide synthase-like Pks11 (1 entity in total)
Functional Keywords	lipid biosynthesis, structural genomics, enzyme function initiative, ketosynthase enzyme, alkylpyrone synthesis, transferase, mycobacterium tuberculosis structural proteomics project, xmtb
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	4
Total formula weight	150724.58
Authors	Gokulan, K.,Sacchettini, J.C.,Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) (deposition date: 2013-02-19, release date: 2013-04-24, Last modification date: 2024-02-28)
Primary citation	Gokulan, K.,O'Leary, S.E.,Russell, W.K.,Russell, D.H.,Lalgondar, M.,Begley, T.P.,Ioerger, T.R.,Sacchettini, J.C. Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. J.Biol.Chem., 288:16484-16494, 2013 Cited by PubMed: 23615910 DOI: 10.1074/jbc.M113.468892 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation