4J14

Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound

Summary for 4J14

Entry DOI	10.2210/pdb4j14/pdb
Related	3MDM 3MDR 3MDT 3MDV 4ENH 4FIA
Descriptor	Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, POSACONAZOLE, ... (5 entities in total)
Functional Keywords	enzyme, p450, posaconazole, oxidoreductase, endoplasmic reticulum, cholesterol 24-hydroxylase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: Q9Y6A2
Total number of polymer chains	1
Total formula weight	53534.44
Authors	Stout, C.D.,Mast, N.,Pikuleva, I.A. (deposition date: 2013-01-31, release date: 2014-01-15, Last modification date: 2023-09-20)
Primary citation	Mast, N.,Zheng, W.,Stout, C.D.,Pikuleva, I.A. Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1. Mol.Pharmacol., 84:86-94, 2013 Cited by PubMed: 23604141 DOI: 10.1124/mol.113.085902 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation