4IZK
Crystal structure of yellowtail ascites virus VP4 protease active site mutant (K674A) reveals both an acyl-enzyme complex and an empty active site
Replaces: 4HHCReplaces: 3RBPSummary for 4IZK
Entry DOI | 10.2210/pdb4izk/pdb |
Related | 2GEF 2PNL 2PNM 3P06 4IZJ |
Descriptor | Yellowtail Ascites Virus (YAV) VP4 protease, MAGNESIUM ION, BETA-MERCAPTOETHANOL, ... (5 entities in total) |
Functional Keywords | viral protease, birnavirus, serine-lysine dyad mechanism, alpha-beta protein fold, lysine general base, acyl-enzyme, product complex, hydrolase |
Biological source | Yellowtail ascites virus More |
Cellular location | Host cytoplasm . Virion : P89521 P89521 |
Total number of polymer chains | 2 |
Total formula weight | 44649.41 |
Authors | Paetzel, M.,Chung, I.Y.W. (deposition date: 2013-01-30, release date: 2013-02-27, Last modification date: 2023-12-06) |
Primary citation | Chung, I.Y.,Paetzel, M. Crystal Structures of Yellowtail Ascites Virus VP4 Protease: TRAPPING AN INTERNAL CLEAVAGE SITE TRANS ACYL-ENZYME COMPLEX IN A NATIVE SER/LYS DYAD ACTIVE SITE. J.Biol.Chem., 288:13068-13081, 2013 Cited by PubMed: 23511637DOI: 10.1074/jbc.M112.386953 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report