4IS6

Crystal structure of HLA-DR4 bound to GP100 peptide

Summary for 4IS6

• Entry DOI: 10.2210/pdb4is6/pdb
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-4 beta chain, Melanocyte protein PMEL, ... (4 entities in total)
• Functional Keywords: mhc class ii, hla-dr4, gp100, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P13760; Endoplasmic reticulum membrane; Single-pass type I membrane protein. M-alpha: Secreted: P40967
• Total number of polymer chains: 3
• Total formula weight: 45783.21

Authors

Li, Y. (deposition date: 2013-01-16, release date: 2013-10-23, Last modification date: 2013-11-20)

• Primary citation: Chen, S.,Li, Y.,Depontieu, F.R.,McMiller, T.L.,English, A.M.,Shabanowitz, J.,Kos, F.,Sidney, J.,Sette, A.,Rosenberg, S.A.,Hunt, D.F.,Mariuzza, R.A.,Topalian, S.L.; Structure-Based Design of Altered MHC Class II-Restricted Peptide Ligands with Heterogeneous Immunogenicity.; J.Immunol., 191:5097-5106, 2013; PubMed: 24108701; DOI: 10.4049/jimmunol.1300467

Experimental method

X-RAY DIFFRACTION (2.5 Å)