4IO8
Crystal structure of human HSP70 complexed with 4-{(2R,3S,4R)-5-[(R)-6-Amino-8-(3,4-dichloro-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxymethyl}-benzonitrile
Summary for 4IO8
Entry DOI | 10.2210/pdb4io8/pdb |
Descriptor | Heat shock 70kDa protein 1A variant, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile (3 entities in total) |
Functional Keywords | hsp70, atpase, molecular chaperone, chaperone |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42627.04 |
Authors | Musil, D.,Scholz, S. (deposition date: 2013-01-07, release date: 2013-12-18, Last modification date: 2023-09-20) |
Primary citation | Schlecht, R.,Scholz, S.R.,Dahmen, H.,Wegener, A.,Sirrenberg, C.,Musil, D.,Bomke, J.,Eggenweiler, H.M.,Mayer, M.P.,Bukau, B. Functional analysis of hsp70 inhibitors. Plos One, 8:e78443-e78443, 2013 Cited by PubMed: 24265689DOI: 10.1371/journal.pone.0078443 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.58 Å) |
Structure validation
Download full validation report