4IKF

PFV intasome with inhibitor MB-76

Summary for 4IKF

• Entry DOI: 10.2210/pdb4ikf/pdb
• Descriptor: Integrase, N-(4-fluorobenzyl)-2,3-dihydroxy-1-oxo-1,2-dihydroisoquinoline-4-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', ... (10 entities in total)
• Functional Keywords: integrase zinc binding, core and dna-binding domains, dna integration, inhibitor, nucleus, viral protein-dna-inhibitor complex, endonuclease, nucleotidyltransferase, recombination, hhcc motif, dde motif, viral protein/dna/inhibitor
• Biological source: Human spumaretrovirus (SFVcpz(hu))
• Total number of polymer chains: 4
• Total formula weight: 101082.61

Authors

Taltynov, O.,Demeulemeester, J.,Desimmie, B.A.,Suchaud, V.,Billamboz, M.,Lion, C.,Bailly, F.,Debyser, Z.,Cotelle, P.,Christ, F.,Strelkov, S.V. (deposition date: 2012-12-26, release date: 2013-04-03, Last modification date: 2024-02-28)

• Primary citation: Desimmie, B.A.,Demeulemeester, J.,Suchaud, V.,Taltynov, O.,Billamboz, M.,Lion, C.,Bailly, F.,Strelkov, S.V.,Debyser, Z.,Cotelle, P.,Christ, F.; 2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance.; Acs Chem.Biol., 8:1187-1194, 2013; PubMed: 23517458; DOI: 10.1021/cb4000426

Experimental method

X-RAY DIFFRACTION (3.4 Å)