4II5

Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION

Summary for 4II5

• Entry DOI: 10.2210/pdb4ii5/pdb
• Related: 4I3Z
• Descriptor: Cyclin-dependent kinase 2, Cyclin-A2, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: adp and magnesium binding, t160 phosphorylation, transferase-cell cycle complex, transferase/cell cycle
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton, centrosome: P24941; Nucleus: P51943
• Total number of polymer chains: 4
• Total formula weight: 128764.83

Authors

Jacobsen, D.M.,Bao, Z.-Q.,O'Brien, P.J.,Brooks III, C.L.,Young, M.A. (deposition date: 2012-12-19, release date: 2013-01-23)

• Primary citation: Jacobsen, D.M.,Bao, Z.-Q.,O'Brien, P.J.,Brooks III, C.L.,Young, M.A.; Price to be paid for two-metal catalysis: Magnesium ions that accelerate chemistry unavoidably limit product release from a PROTEIN KINASE; J.Am.Chem.Soc., 134:15357-, 2012; PubMed: 22891849

Experimental method

X-RAY DIFFRACTION (2.15 Å)