4IHO

Crystal structure of H-2Db Y159F in complex with chimeric gp100

Summary for 4IHO

Entry DOI	10.2210/pdb4iho/pdb
Related	3CCH 3CH1
Descriptor	H-2 class I histocompatibility antigen, D-B alpha chain, Beta-2-microglobulin, NONAMERIC PEPTIDE CHIMERIC GP100, ... (6 entities in total)
Functional Keywords	mhc, h-2db, glycoprotein, immune response, mhc i, transmembrane, immunoglobulin domain, disease mutation, melanoma, immune system, tumor associated antigen, altered peptide ligand, t cell receptor
Biological source	Mus musculus (mouse) More
Cellular location	Membrane; Single-pass type I membrane protein: P01899 Secreted: P01887
Total number of polymer chains	6
Total formula weight	90154.82
Authors	Uchtenhagen, H.,Stahl, E.,Achour, A. (deposition date: 2012-12-19, release date: 2013-09-11, Last modification date: 2023-11-08)
Primary citation	Uchtenhagen, H.,Abualrous, E.T.,Stahl, E.,Allerbring, E.B.,Sluijter, M.,Zacharias, M.,Sandalova, T.,van Hall, T.,Springer, S.,Nygren, P.A.,Achour, A. Proline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptides Eur.J.Immunol., 43:3051-3060, 2013 Cited by PubMed: 23939911 DOI: 10.1002/eji.201343456 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation