4IHL

Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A

Summary for 4IHL

• Entry DOI: 10.2210/pdb4ihl/pdb
• Related: 1A4O 1IB1 1QJA 1QJB 3E6Y 3SMK 4FJ3 4IEA
• Descriptor: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: 14-3-3 fold, raf, all alpha-helical, adapter protein, protein-protein interaction, peptide binding protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P63104 P04049
• Total number of polymer chains: 3
• Total formula weight: 58948.32

Authors

Molzan, M.,Ottmann, C. (deposition date: 2012-12-19, release date: 2013-09-25, Last modification date: 2023-09-20)

• Primary citation: Molzan, M.,Kasper, S.,Roglin, L.,Skwarczynska, M.,Sassa, T.,Inoue, T.,Breitenbuecher, F.,Ohkanda, J.,Kato, N.,Schuler, M.,Ottmann, C.; Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers.; Acs Chem.Biol., 8:1869-1875, 2013; PubMed: 23808890; DOI: 10.1021/cb4003464

Experimental method

X-RAY DIFFRACTION (2.2 Å)