4IGR

Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist ZA302

Summary for 4IGR

Entry DOI	10.2210/pdb4igr/pdb
Related	3S9E 4IGT
Descriptor	Glutamate receptor, ionotropic kainate 3, (4R)-4-{3-[hydroxy(methyl)amino]-3-oxopropyl}-L-glutamic acid, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	membrane protein, ionotropic glutamate receptor, kainate receptor, ligand-binding domain, agonist
Biological source	Rattus norvegicus (rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P42264
Total number of polymer chains	1
Total formula weight	29549.31
Authors	Larsen, A.P.,Venskutonyte, R.,Gajhede, M.,Kastrup, J.S.,Frydenvang, K. (deposition date: 2012-12-18, release date: 2013-03-06, Last modification date: 2023-11-08)
Primary citation	Assaf, Z.,Larsen, A.P.,Venskutonyte, R.,Han, L.,Abrahamsen, B.,Nielsen, B.,Gajhede, M.,Kastrup, J.S.,Jensen, A.A.,Pickering, D.S.,Frydenvang, K.,Gefflaut, T.,Bunch, L. Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. J.Med.Chem., 56:1614-1628, 2013 Cited by PubMed: 23414088 DOI: 10.1021/jm301433m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation