4IG8
Structural basis for cytosolic double-stranded RNA surveillance by human OAS1
Summary for 4IG8
Entry DOI | 10.2210/pdb4ig8/pdb |
Descriptor | 2'-5'-oligoadenylate synthase 1, RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*C)-3'), RNA (5'-R(*GP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3'), ... (6 entities in total) |
Functional Keywords | nucleotidyl transferase, innate immune system double-stranded dsrna sensor rna polymerase, nucleotidyl transferase 2-5a synthetase, rnase l activator, double-stranded rna, cytosol, transferase-rna complex, transferase/rna |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00973 |
Total number of polymer chains | 3 |
Total formula weight | 52141.89 |
Authors | Donovan, J.,Korennykh, A. (deposition date: 2012-12-16, release date: 2013-01-16, Last modification date: 2024-02-28) |
Primary citation | Donovan, J.,Dufner, M.,Korennykh, A. Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1. Proc.Natl.Acad.Sci.USA, 110:1652-1657, 2013 Cited by PubMed: 23319625DOI: 10.1073/pnas.1218528110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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