4IEM
Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+
Summary for 4IEM
Entry DOI | 10.2210/pdb4iem/pdb |
Related | 4IEK |
Descriptor | DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(*GP*CP*TP*AP*C)-3'), DNA (5'-D(P*(3DR)P*GP*AP*TP*CP*G)-3'), ... (7 entities in total) |
Functional Keywords | metalloprotein, dna damage, dna repair, base excision repair, protein-dna, ref1, nuclease, hydrolase, lyase-dna complex, lyase/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus. DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion: P27695 |
Total number of polymer chains | 16 |
Total formula weight | 168495.63 |
Authors | Tsutakawa, S.E.,Mol, C.D.,Arvai, A.S.,Tainer, J.A. (deposition date: 2012-12-13, release date: 2013-01-23, Last modification date: 2024-02-28) |
Primary citation | Tsutakawa, S.E.,Shin, D.S.,Mol, C.D.,Izumi, T.,Arvai, A.S.,Mantha, A.K.,Szczesny, B.,Ivanov, I.N.,Hosfield, D.J.,Maiti, B.,Pique, M.E.,Frankel, K.A.,Hitomi, K.,Cunningham, R.P.,Mitra, S.,Tainer, J.A. Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes. J.Biol.Chem., 288:8445-8455, 2013 Cited by PubMed: 23355472DOI: 10.1074/jbc.M112.422774 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3936 Å) |
Structure validation
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