4IBC

Ebola virus VP35 bound to small molecule

Summary for 4IBC

Entry DOI	10.2210/pdb4ibc/pdb
Related	4IBB 4IBD 4IBE 4IBF 4IBG 4IBH 4IBI 4IBJ 4IBK
Descriptor	Polymerase cofactor VP35, {4-[(2R)-3-(2-chlorobenzoyl)-2-(2-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	interferon inhibitor domain, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Ebola virus (ZEBOV)
Total number of polymer chains	2
Total formula weight	29463.80
Authors	Brown, C.S.,Leung, D.W.,Xu, W.,Borek, D.M.,Otwinowski, Z.,Ramanan, P.,Stubbs, A.J.,Peterson, D.S.,Binning, J.M.,Amarasinghe, G.K. (deposition date: 2012-12-08, release date: 2014-03-19, Last modification date: 2024-02-28)
Primary citation	Brown, C.S.,Lee, M.S.,Leung, D.W.,Wang, T.,Xu, W.,Luthra, P.,Anantpadma, M.,Shabman, R.S.,Melito, L.M.,Macmillan, K.S.,Borek, D.M.,Otwinowski, Z.,Ramanan, P.,Stubbs, A.J.,Peterson, D.S.,Binning, J.M.,Tonelli, M.,Olson, M.A.,Davey, R.A.,Ready, J.M.,Basler, C.F.,Amarasinghe, G.K. In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426:2045-2058, 2014 Cited by PubMed: 24495995 DOI: 10.1016/j.jmb.2014.01.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.745 Å)

Structure validation