4I7Y

Crystal Structure of Human Alpha Thrombin in Complex with a 27-mer Aptamer Bound to Exosite II

Summary for 4I7Y

Entry DOI	10.2210/pdb4i7y/pdb
Related	3QLP 4DIH 4DII
Related PRD ID	PRD_000020
Descriptor	Prothrombin, DNA (27-MER), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (7 entities in total)
Functional Keywords	protein-dna complex, serine protease, blood coagulation, aptamer, hydrolase-hydrolase inhibitor-dna complex, serine protease fold, dna aptamer, blood, g-quadruplex, duplex-quadruplex junction, hydrolase/hydrolase inhibitor/dna
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	43060.37
Authors	Pica, A.,Russo Krauss, I.,Merlino, A.,Mazzarella, L.,Sica, F. (deposition date: 2012-12-01, release date: 2013-10-16, Last modification date: 2020-07-29)
Primary citation	Russo Krauss, I.,Pica, A.,Merlino, A.,Mazzarella, L.,Sica, F. Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer. Acta Crystallogr.,Sect.D, 69:2403-2411, 2013 Cited by PubMed: 24311581 DOI: 10.1107/S0907444913022269 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation