4I2Q
Crystal structure of K103N/Y181C mutant of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) analogue
Summary for 4I2Q
Entry DOI | 10.2210/pdb4i2q/pdb |
Descriptor | Gag-Pol polyprotein, (2E)-3-(4-{[6-(1,3-benzothiazol-5-ylamino)-9H-purin-2-yl]amino}-3,5-dimethylphenyl)prop-2-enenitrile, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Human immunodeficiency virus type 1 BH10 (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 114454.19 |
Authors | Patel, D.,Bauman, J.D.,Das, K.,Arnold, E. (deposition date: 2012-11-22, release date: 2013-01-16, Last modification date: 2024-02-28) |
Primary citation | Johnson, B.C.,Pauly, G.T.,Rai, G.,Patel, D.,Bauman, J.D.,Baker, H.L.,Das, K.,Schneider, J.P.,Maloney, D.J.,Arnold, E.,Thomas, C.J.,Hughes, S.H. A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. Retrovirology, 9:99-99, 2012 Cited by PubMed: 23217210DOI: 10.1186/1742-4690-9-99 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7004 Å) |
Structure validation
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