4HZH

Structure of recombinant Gla-domainless prothrombin mutant S525A

Summary for 4HZH

Entry DOI	10.2210/pdb4hzh/pdb
Related	3NXP 4HZQ
Descriptor	Prothrombin, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywords	prothrombin, kringle, serine protease, coagulation, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	121115.60
Authors	Pozzi, N.,Niu, W.,Gohara, D.W.,Chen, Z.,Di Cera, E. (deposition date: 2012-11-15, release date: 2013-06-26, Last modification date: 2023-09-20)
Primary citation	Pozzi, N.,Chen, Z.,Gohara, D.W.,Niu, W.,Heyduk, T.,Di Cera, E. Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation. J.Biol.Chem., 288:22734-22744, 2013 Cited by PubMed: 23775088 DOI: 10.1074/jbc.M113.466946 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation