4HT0

Crystal structure of human carbonic anhydrase isozyme II with the inhibitor.

Summary for 4HT0

Entry DOI	10.2210/pdb4ht0/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, carbon-oxygen lyase activity, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29995.18
Authors	Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2012-10-31, release date: 2013-04-10, Last modification date: 2023-09-20)
Primary citation	Dudutiene, V.,Zubriene, A.,Smirnov, A.,Gylyte, J.,Timm, D.,Manakova, E.,Grazulis, S.,Matulis, D. 4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII. Bioorg.Med.Chem., 21:2093-2106, 2013 Cited by PubMed: 23394791 DOI: 10.1016/j.bmc.2013.01.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation