4HOE
Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E)
Summary for 4HOE
Entry DOI | 10.2210/pdb4hoe/pdb |
Related | 3QLR 3QLS 3QLW 4H95 4H96 4H97 4H98 4HOF 4HOG |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (6 entities in total) |
Functional Keywords | antifungal agents, candida albicans, drug design, enzyme inhibitors, fungal proteins, structure-activity relationship, tetrahydrofolate dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Candida albicans (yeast) |
Total number of polymer chains | 2 |
Total formula weight | 46916.07 |
Authors | Paulsen, J.L.,Anderson, A.C. (deposition date: 2012-10-22, release date: 2014-03-19, Last modification date: 2023-09-20) |
Primary citation | G-Dayanandan, N.,Paulsen, J.L.,Viswanathan, K.,Keshipeddy, S.,Lombardo, M.N.,Zhou, W.,Lamb, K.M.,Sochia, A.E.,Alverson, J.B.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata. J.Med.Chem., 57:2643-2656, 2014 Cited by PubMed: 24568657DOI: 10.1021/jm401916j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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