4HNI
crystal structure of ck1e in complex with PF4800567
Summary for 4HNI
Entry DOI | 10.2210/pdb4hni/pdb |
Related | 4HNK 4HOK |
Descriptor | Casein kinase I isoform epsilon, 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | ck1e, kinase, inhibitor, pf4800567, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 70215.41 |
Authors | Huang, X.,Long, A.M.,Zhao, H. (deposition date: 2012-10-19, release date: 2012-11-14, Last modification date: 2024-02-28) |
Primary citation | Long, A.M.,Zhao, H.,Huang, X. Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J.Med.Chem., 55:10307-10311, 2012 Cited by PubMed: 23106386DOI: 10.1021/jm301336n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.74 Å) |
Structure validation
Download full validation report