4HJT
Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide
Summary for 4HJT
Entry DOI | 10.2210/pdb4hjt/pdb |
Related | 3CN0 3CN1 3HJO 3IMR 3IMT 4HJS 4HJU |
Descriptor | Transthyretin, N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}propanamide (3 entities in total) |
Functional Keywords | hormone binding protein, thyroxine, retinol binding protein, hormone binding protein-inhibitor complex, hormone binding protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28145.47 |
Authors | Connelly, S.,Wilson, I.A. (deposition date: 2012-10-14, release date: 2013-12-04, Last modification date: 2023-09-20) |
Primary citation | Suh, E.H.,Liu, Y.,Connelly, S.,Genereux, J.C.,Wilson, I.A.,Kelly, J.W. Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135:17869-17880, 2013 Cited by PubMed: 24180271DOI: 10.1021/ja408230k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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