4HGE

JAK2 kinase (JH1 domain) in complex with compound 8

Summary for 4HGE

Entry DOI	10.2210/pdb4hge/pdb
Descriptor	Tyrosine-protein kinase JAK2, N-[1-(3-chlorophenyl)-3-methyl-1H-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total)
Functional Keywords	protein kinase, phosphotransfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endomembrane system; Peripheral membrane protein (By similarity): O60674
Total number of polymer chains	2
Total formula weight	71389.81
Authors	Eigenbrot, C.,Ultsch, M. (deposition date: 2012-10-08, release date: 2012-10-24, Last modification date: 2023-12-06)
Primary citation	Hanan, E.J.,van Abbema, A.,Barrett, K.,Blair, W.S.,Blaney, J.,Chang, C.,Eigenbrot, C.,Flynn, S.,Gibbons, P.,Hurley, C.A.,Kenny, J.R.,Kulagowski, J.,Lee, L.,Magnuson, S.R.,Morris, C.,Murray, J.,Pastor, R.M.,Rawson, T.,Siu, M.,Ultsch, M.,Zhou, A.,Sampath, D.,Lyssikatos, J.P. Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors. J.Med.Chem., 55:10090-10107, 2012 Cited by PubMed: 23061660 DOI: 10.1021/jm3012239 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation