4HFZ
Crystal Structure of an MDM2/P53 Peptide Complex
Summary for 4HFZ
Entry DOI | 10.2210/pdb4hfz/pdb |
Related | 4HG7 |
Descriptor | E3 ubiquitin-protein ligase Mdm2, Cellular tumor antigen p53, SULFATE ION, ... (4 entities in total) |
Functional Keywords | mdm2, p53, surface entropy reduction, mutant validation, ligase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus, nucleoplasm: Q00987 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 4 |
Total formula weight | 28550.43 |
Authors | Anil, B.,Riedinger, C.,Endicott, J.A.,Noble, M.E.M. (deposition date: 2012-10-05, release date: 2013-07-31, Last modification date: 2024-02-28) |
Primary citation | Anil, B.,Riedinger, C.,Endicott, J.A.,Noble, M.E. The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant. Acta Crystallogr.,Sect.D, 69:1358-1366, 2013 Cited by PubMed: 23897459DOI: 10.1107/S0907444913004459 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.694 Å) |
Structure validation
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