4HFP
Structure of thrombin mutant S195a bound to the active site inhibitor argatroban
Summary for 4HFP
Entry DOI | 10.2210/pdb4hfp/pdb |
Related | 1SHH 4HFY |
Related PRD ID | PRD_000889 |
Descriptor | Prothrombin, SODIUM ION, (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid, ... (5 entities in total) |
Functional Keywords | serine protease, prethrombin-2, autoactivation, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 4 |
Total formula weight | 67885.84 |
Authors | Pozzi, N.,Chen, Z.,Zapata, F.,Lin, W.,Barranco-Medina, S.,Pelc, L.A.,Di Cera, E. (deposition date: 2012-10-05, release date: 2013-03-13, Last modification date: 2023-09-20) |
Primary citation | Pozzi, N.,Chen, Z.,Zapata, F.,Niu, W.,Barranco-Medina, S.,Pelc, L.A.,Di Cera, E. Autoactivation of thrombin precursors. J.Biol.Chem., 288:11601-11610, 2013 Cited by PubMed: 23467412DOI: 10.1074/jbc.M113.451542 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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