4HD0

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair

Summary for 4HD0

• Entry DOI: 10.2210/pdb4hd0/pdb
• Descriptor: DNA double-strand break repair protein Mre11, MANGANESE (II) ION (3 entities in total)
• Functional Keywords: nuclease enzyme, double-strand break repair, rad50, nbs1, mutation l204r, dna binding protein
• Biological source: Pyrococcus furiosus
• Total number of polymer chains: 2
• Total formula weight: 79822.74

Authors

Limbo, O.,Moiani, D.,Kertokalio, A.,Wyman, C.,Tainer, J.A.,Russell, P. (deposition date: 2012-10-01, release date: 2012-10-31, Last modification date: 2024-02-28)

• Primary citation: Limbo, O.,Moiani, D.,Kertokalio, A.,Wyman, C.,Tainer, J.A.,Russell, P.; Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.; Nucleic Acids Res., 40:11435-11449, 2012; PubMed: 23080121; DOI: 10.1093/nar/gks954

Experimental method

X-RAY DIFFRACTION (2.3 Å)