4GRL

Crystal structure of a autoimmune TCR-MHC complex

Summary for 4GRL

Entry DOI	10.2210/pdb4grl/pdb
Related	3PL6 4MAY
Descriptor	MHC class II HLA-DQ-alpha chain, MHC class II antigen, TCR Hy.1B11 alpha chain, ... (6 entities in total)
Functional Keywords	immune complex, peptide antigen presentation, multiple sclerosis, autoimmunity, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	97019.84
Authors	Sethi, D.K.,Wucherpfennig, K.W. (deposition date: 2012-08-25, release date: 2013-11-06, Last modification date: 2020-07-29)
Primary citation	Sethi, D.K.,Gordo, S.,Schubert, D.A.,Wucherpfennig, K.W. Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop. Nat Commun, 4:2623-2623, 2013 Cited by PubMed: 24136005 DOI: 10.1038/ncomms3623 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.86 Å)

Structure validation