4GPL

Structure of Cbl(TKB) bound to a phosphorylated pentapeptide

Summary for 4GPL

• Entry DOI: 10.2210/pdb4gpl/pdb
• Descriptor: ACE-PTR-THR-PRO-GLU-PRO, PEPTIDE INHIBITOR, E3 ubiquitin-protein ligase CBL (3 entities in total)
• Functional Keywords: ubiquitin ligase(e3), ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P22681
• Total number of polymer chains: 2
• Total formula weight: 36553.10

Authors

Borgstahl, G.,Natarajan, A. (deposition date: 2012-08-21, release date: 2013-09-18, Last modification date: 2023-12-06)

• Primary citation: Kumar, E.A.,Chen, Q.,Kizhake, S.,Kolar, C.,Kang, M.,Chang, C.E.,Borgstahl, G.E.,Natarajan, A.; The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides.; Sci Rep, 3:1639-1639, 2013; PubMed: 23572190; DOI: 10.1038/srep01639

Experimental method

X-RAY DIFFRACTION (3 Å)