4GLX
DNA ligase A in complex with inhibitor
Summary for 4GLX
Entry DOI | 10.2210/pdb4glx/pdb |
Related | 3baa 4GLW |
Descriptor | DNA (26-MER), DNA (5'-D(*AP*CP*AP*AP*TP*TP*GP*CP*GP*AP*CP*CP*C)-3'), DNA (5'-D(P*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*TP*G)-3'), ... (8 entities in total) |
Functional Keywords | dna ligase a, inhibitor, ligase-ligase inhibitor-dna complex, ligase/ligase inhibitor/dna |
Biological source | Escherichia coli More |
Total number of polymer chains | 4 |
Total formula weight | 81352.74 |
Authors | Prade, L.,Lange, R.,Tidten-Luksch, N.,Chambovey, A. (deposition date: 2012-08-15, release date: 2012-10-10, Last modification date: 2024-02-28) |
Primary citation | Surivet, J.P.,Lange, R.,Hubschwerlen, C.,Keck, W.,Specklin, J.L.,Ritz, D.,Bur, D.,Locher, H.,Seiler, P.,Strasser, D.S.,Prade, L.,Kohl, C.,Schmitt, C.,Chapoux, G.,Ilhan, E.,Ekambaram, N.,Athanasiou, A.,Knezevic, A.,Sabato, D.,Chambovey, A.,Gaertner, M.,Enderlin, M.,Boehme, M.,Sippel, V.,Wyss, P. Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity. Bioorg.Med.Chem.Lett., 22:6705-6711, 2012 Cited by PubMed: 23006603DOI: 10.1016/j.bmcl.2012.08.094 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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