4GD8

SHV-1 beta-lactamase in complex with penam sulfone SA3-53

Summary for 4GD8

Entry DOI	10.2210/pdb4gd8/pdb
Related	3D4F 4GD6 4GDB
Descriptor	Beta-lactamase SHV-1, (2S,3R)-4-(2-aminoethylcarbamoyloxy)-2-[(2-methanoylindolizin-3-yl)amino]-3-methyl-3-sulfino-butanoic acid, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (4 entities in total)
Functional Keywords	class a beta-lactamase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	32703.63
Authors	Pattanaik, P.,van den Akker, F. (deposition date: 2012-07-31, release date: 2013-07-31, Last modification date: 2013-08-07)
Primary citation	Ke, W.,Pattanaik, P.,Bethel, C.R.,Sheri, A.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F. Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation Plos One, 7:e49035-e49035, 2012 Cited by PubMed: 23145056 DOI: 10.1371/journal.pone.0049035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation