4G17
Crystal structure of ck1g3 with 2-[(4-TERT-BUTYLPHENYL)AMINO]-1H-BENZIMIDAZOLE-6-CARBONITRILE
Summary for 4G17
Entry DOI | 10.2210/pdb4g17/pdb |
Related | 4G16 |
Descriptor | Casein kinase I isoform gamma-3, 2-[(4-tert-butylphenyl)amino]-1H-benzimidazole-6-carbonitrile (3 entities in total) |
Functional Keywords | ck1g, kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9Y6M4 |
Total number of polymer chains | 1 |
Total formula weight | 38759.58 |
Authors | Huang, X. (deposition date: 2012-07-10, release date: 2013-05-22, Last modification date: 2023-09-13) |
Primary citation | Hua, Z.,Huang, X.,Bregman, H.,Chakka, N.,DiMauro, E.F.,Doherty, E.M.,Goldstein, J.,Gunaydin, H.,Huang, H.,Mercede, S.,Newcomb, J.,Patel, V.F.,Turci, S.M.,Yan, J.,Wilson, C.,Martin, M.W. 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1g)inhibitors Bioorg.Med.Chem.Lett., 22:5392-5395, 2012 Cited by PubMed: 22877629DOI: 10.1016/j.bmcl.2012.07.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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