4G11

X-ray structure of PI3K-gamma bound to a 4-(morpholin-4-yl)- (6-oxo-1,6-dihydropyrimidin-2-yl)amide inhibitor

Summary for 4G11

Entry DOI	10.2210/pdb4g11/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]-N-phenylacetamide (2 entities in total)
Functional Keywords	phosphoinositide 3-kinase gamma, secondary messenger generation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P48736
Total number of polymer chains	1
Total formula weight	111041.44
Authors	Morales, R. (deposition date: 2012-07-10, release date: 2012-11-14, Last modification date: 2023-09-13)
Primary citation	Certal, V.,Halley, F.,Virone-Oddos, A.,Thompson, F.,Filoche-Romme, B.,El-Ahmad, Y.,Carry, J.C.,Delorme, C.,Karlsson, A.,Abecassis, P.Y.,Vincent, L.,Bonnevaux, H.,Nicolas, J.P.,Morales, R.,Michot, N.,Vade, I.,Louboutin, A.,Perron, S.,Doerflinger, G.,Tric, B.,Monget, S.,Lengauer, C.,Schio, L. Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3K beta inhibitors Bioorg.Med.Chem.Lett., 22:6381-6384, 2012 Cited by PubMed: 22981333 DOI: 10.1016/j.bmcl.2012.08.072 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation