4FXY

Crystal structure of rat neurolysin with bound pyrazolidin inhibitor

Summary for 4FXY

Entry DOI	10.2210/pdb4fxy/pdb
Related	1I1I 2O3E
Descriptor	Neurolysin, mitochondrial, 1-{(2S)-1-[(3R)-3-(2-chlorophenyl)-2-(2-fluorophenyl)pyrazolidin-1-yl]-1-oxopropan-2-yl}-3-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]urea, ZINC ION, ... (4 entities in total)
Functional Keywords	hydrolase, endopeptidase, zinc metallopeptidase, neuropeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Rattus norvegicus (rat)
Total number of polymer chains	2
Total formula weight	159936.23
Authors	Rodgers, D.W.,Hines, C.S. (deposition date: 2012-07-03, release date: 2013-11-13, Last modification date: 2023-09-13)
Primary citation	Hines, C.S.,Ray, K.,Schmidt, J.J.,Xiong, F.,Feenstra, R.W.,Pras-Raves, M.,de Moes, J.P.,Lange, J.H.,Melikishvili, M.,Fried, M.G.,Mortenson, P.,Charlton, M.,Patel, Y.,Courtney, S.M.,Kruse, C.G.,Rodgers, D.W. Allosteric inhibition of the neuropeptidase neurolysin. J.Biol.Chem., 289:35605-35619, 2014 Cited by PubMed: 25378390 DOI: 10.1074/jbc.M114.620930 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation