4FEA
Crystal structure of CASPASE-7 in Complex with allosteric inhibitor
Summary for 4FEA
Entry DOI | 10.2210/pdb4fea/pdb |
Related | 4FDL |
Descriptor | Caspase-7, chloro{methyl hydrogenato(3-)-kappa~2~N,S [pyridin-2-yl(pyridin-2(1H)-ylidene-kappaN)methyl]carbonodithiohydrazonate}copper (2 entities in total) |
Functional Keywords | cysteine protease, apoptosis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P55210 |
Total number of polymer chains | 2 |
Total formula weight | 56946.60 |
Authors | Kabaleeswaran, V. (deposition date: 2012-05-29, release date: 2012-08-01, Last modification date: 2023-09-13) |
Primary citation | Feldman, T.,Kabaleeswaran, V.,Jang, S.B.,Antczak, C.,Djaballah, H.,Wu, H.,Jiang, X. A class of allosteric caspase inhibitors identified by high-throughput screening. Mol.Cell, 47:585-595, 2012 Cited by PubMed: 22795132DOI: 10.1016/j.molcel.2012.06.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.79 Å) |
Structure validation
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