4EYR

Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir

Summary for 4EYR

• Entry DOI: 10.2210/pdb4eyr/pdb
• Related: 1TW7 3OQ7
• Related PRD ID: PRD_001001
• Descriptor: HIV-1 PROTEASE, RITONAVIR (3 entities in total)
• Functional Keywords: protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22260.21

Authors

Liu, Z.,Yedidi, R.S.,Wang, Y.,Brunzelle, J.S.,Kovari, I.A.,Kovari, L.C. (deposition date: 2012-05-01, release date: 2013-01-30, Last modification date: 2024-02-28)

• Primary citation: Liu, Z.,Yedidi, R.S.,Wang, Y.,Dewdney, T.G.,Reiter, S.J.,Brunzelle, J.S.,Kovari, I.A.,Kovari, L.C.; Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex.; Biochem.Biophys.Res.Commun., 431:232-238, 2013; PubMed: 23313846; DOI: 10.1016/j.bbrc.2012.12.127

Experimental method

X-RAY DIFFRACTION (1.8 Å)