4EY8

Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2

Summary for 4EY8

Entry DOI	10.2210/pdb4ey8/pdb
Descriptor	Acetylcholinesterase, Fasciculin-2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	acetylcholinesterase, hydrolase, fasciculin 2, snake venom toxin, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	67554.02
Authors	Cheung, J.,Rudolph, M.,Burshteyn, F.,Cassidy, M.,Gary, E.,Love, J.,Height, J.,Franklin, M. (deposition date: 2012-05-01, release date: 2012-10-17, Last modification date: 2023-09-13)
Primary citation	Cheung, J.,Rudolph, M.J.,Burshteyn, F.,Cassidy, M.S.,Gary, E.N.,Love, J.,Franklin, M.C.,Height, J.J. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem., 55:10282-10286, 2012 Cited by PubMed: 23035744 DOI: 10.1021/jm300871x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5958 Å)

Structure validation