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4EV4

Crystal structure of serratia fonticola carbapenemase SFC-1 E166A mutant with the acylenzyme intermediate of meropenem

Summary for 4EV4
Entry DOI10.2210/pdb4ev4/pdb
Related4EQI 4EUZ
DescriptorCarbapenem-hydrolizing beta-lactamase SFC-1, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordscarbapenemase, hydrolase, antibiotic resistance, beta-lactamase complex, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourceSerratia fonticola
Total number of polymer chains1
Total formula weight31401.48
Authors
Fonseca, F.,Spencer, J. (deposition date: 2012-04-25, release date: 2012-05-23, Last modification date: 2023-09-13)
Primary citationFonseca, F.,Chudyk, E.I.,van der Kamp, M.W.,Correia, A.,Mulholland, A.J.,Spencer, J.
The basis for carbapenem hydrolysis by class A beta-lactamases: a combined investigation using crystallography and simulations.
J.Am.Chem.Soc., 134:18275-18285, 2012
Cited by
PubMed: 23030300
DOI: 10.1021/ja304460j
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.3 Å)
Structure validation

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