4EUU

Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172

Summary for 4EUU

• Entry DOI: 10.2210/pdb4euu/pdb
• Related: 4EUT
• Descriptor: Serine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, IODIDE ION, ... (6 entities in total)
• Functional Keywords: kinase, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q9UHD2
• Total number of polymer chains: 2
• Total formula weight: 74727.57

Authors

Ma, X.,Helgason, E.,Phung, Q.T.,Quan, C.L.,Iyer, R.S.,Lee, M.W.,Bowman, K.K.,Starovasnik, M.A.,Dueber, E.C. (deposition date: 2012-04-25, release date: 2012-05-23, Last modification date: 2017-11-15)

• Primary citation: Ma, X.,Helgason, E.,Phung, Q.T.,Quan, C.L.,Iyer, R.S.,Lee, M.W.,Bowman, K.K.,Starovasnik, M.A.,Dueber, E.C.; Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.; Proc.Natl.Acad.Sci.USA, 109:9378-9383, 2012; PubMed: 22619329; DOI: 10.1073/pnas.1121552109

Experimental method

X-RAY DIFFRACTION (1.8 Å)