4EQC

Crystal structure of PAK1 kinase domain in complex with FRAX597 inhibitor

Summary for 4EQC

Entry DOI	10.2210/pdb4eqc/pdb
Descriptor	Serine/threonine-protein kinase PAK 1, 6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	serine/threonine kinase, phosphorylation, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q13153
Total number of polymer chains	1
Total formula weight	34456.73
Authors	Maksimoska, J.,Marmorstein, R. (deposition date: 2012-04-18, release date: 2013-08-28, Last modification date: 2023-09-13)
Primary citation	Licciulli, S.,Maksimoska, J.,Zhou, C.,Troutman, S.,Kota, S.,Liu, Q.,Duron, S.,Campbell, D.,Chernoff, J.,Field, J.,Marmorstein, R.,Kissil, J.L. FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas. J.Biol.Chem., 288:29105-29114, 2013 Cited by PubMed: 23960073 DOI: 10.1074/jbc.M113.510933 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation