4EKL
Akt1 with GDC0068
Summary for 4EKL
Entry DOI | 10.2210/pdb4ekl/pdb |
Related | 4EKK |
Descriptor | RAC-alpha serine/threonine-protein kinase, (2S)-2-(4-chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one (3 entities in total) |
Functional Keywords | phosphotransferase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P31749 |
Total number of polymer chains | 1 |
Total formula weight | 39924.96 |
Authors | Wu, W.-I.,Vigers, G.P.A.,Morales, T.H.,Brandhuber, B.J. (deposition date: 2012-04-09, release date: 2012-05-23, Last modification date: 2018-01-24) |
Primary citation | Lin, K.,Lin, J.,Wu, W.I.,Ballard, J.,Lee, B.B.,Gloor, S.L.,Vigers, G.P.,Morales, T.H.,Friedman, L.S.,Skelton, N.,Brandhuber, B.J. An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt. Sci.Signal., 5:ra37-ra37, 2012 Cited by PubMed: 22569334DOI: 10.1126/scisignal.2002618 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report