4EB4

Crystal structure of mouse thymidylate synthase in ternary complex with dUMP and Tomudex

Summary for 4EB4

Entry DOI	10.2210/pdb4eb4/pdb
Descriptor	Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, ... (8 entities in total)
Functional Keywords	ternary complex, methyltransferase, nucleotide biosynthesis, transferase
Biological source	Mus musculus (mouse)
Cellular location	Nucleus : P07607
Total number of polymer chains	4
Total formula weight	144437.23
Authors	Dowiercial, A.,Jarmula, A.,Rypniewski, W.R.,Wilk, P.,Rode, W. (deposition date: 2012-03-23, release date: 2012-05-02, Last modification date: 2024-02-28)
Primary citation	Dowiercial, A.,Wilk, P.,Rypniewski, W.,Rode, W.,Jarmula, A. Crystal structure of mouse thymidylate synthase in tertiary complex with dUMP and raltitrexed reveals N-terminus architecture and two different active site conformations. Biomed Res Int, 2014:945803-, 2014 Cited by PubMed: 24995339 DOI: 10.1155/2014/945803 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation