4DY7
Crystal structures of protease nexin-1 in complex with S195A thrombin
Summary for 4DY7
Entry DOI | 10.2210/pdb4dy7/pdb |
Descriptor | Thrombin light chain, Thrombin heavy chain, Glia-derived nexin, ... (7 entities in total) |
Functional Keywords | serpin, protease, heparin, cell surface, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 P07093 |
Total number of polymer chains | 6 |
Total formula weight | 154922.04 |
Authors | |
Primary citation | Li, W.,Huntington, J.A. Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism. Blood, 120:459-467, 2012 Cited by PubMed: 22618708DOI: 10.1182/blood-2012-03-415869 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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